Decoding Genomic Dark Matter

We design novel synthetic promoters to control cell-type selective gene expression for our clients

Our Platform

By mining the genome using our bioinformatics platform we discover and re-purpose natural gene regulatory elements, creating customised gene expression systems to:

Improve human health


Creating highly selective and controllable promoters and gene expression cassettes for novel gene and cell therapy systems


Improving the efficiency of biologics production by increasing protein yields in upstream manufacturing processes

Engineer biology


Harnessing synthetic biology by making promoters for the wide array of chassis organisms used in Industrial Biotech


Creating switches and gene circuits to be employed in any metabolic engineering application

Enable traits discovery


Designing tissue-selective plant synthetic promoters active across  different crop species for Agricultural Biotech applications


Using plant genomics to facilitate the design of environmentally-regulated and pathogen-responsive promoters

Science

By studying large genomic datasets, we can discover genomic sequences vital to gene regulation and develop novel, patentable promoters. Understand more about the scientific basis for our approach.

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Technology

We have developed a platform of algorithms and know-how that analyses diverse genomics datasets and enables the development of novel sequences that are optimised for specific applications. Discover more about our technology.

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Sectors

Precise control of gene expression has applications across cell and gene therapy, biologics manufacturing, industrial biotechnology and agricultural biotechnology.

Cell and Gene
Therapy


Synthetic promoters enable  potent cell-selective gene expression and can be designed to respond to different stimuli.

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Biologics Manufacturing

Highly active promoters are vital to maximise gene expression and deliver increased yields under specific production conditions.

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Industrial Biotechnology

Strong synthetic promoters that are customised to the chassis organism and optimised for expression in the bioreactor.

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Agricultural Biotechnology

Precise control over gene expression in specific tissues increases crop yields and protects non-target plant species.

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News

Learn more about the latest updates from Chromatin Bioscience.

By Michael Roberts 08 Sep, 2023
November 6-8, 2023 | Munich, Germany
By Michael Roberts 01 Apr, 2023
April 25–26, 2023 | London, UK
Cell and Gene on the Med
By Michael Roberts 10 Feb, 2023
April 12-14, 2023 | Barcelona, Spain
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